Title: Is Ferroportin Q248H polymorphism protective against clinical manifestations of Malaria during pregnancy?
Author: Katja Greutelaers
Institution: Institute of Tropical Medicine and International Health, Berlin
Graduate date: 2015-12-16 (W3C-DTF)
Document: Greutelaers_Abstract.pdf
Description: Malaria remains a global health problem with the main burden in sub-Saharan Africa. Pregnant women represent a particular risk group with increased susceptibility and clinical manifestation of the disease. Malaria, but also asymptomatic infections can cause low birth weight, preterm delivery, maternal anaemia and consequently high infant mortality.
Risk and manifestation of malaria is influenced by iron status and host genetics. Ferroportin operates as iron exporter transporting Fe2+ from the cell to the bodys circulation. The prevalence of a common FPN mutation, the Q248H polymorphism, ranges from 2.2 to 13.4% in SSA. The polymorphism influences the iron homeostasis and is associated with altered immune responses. The influence of the polymorphism on malaria susceptibility was not explored so far.
Classification: 2015 (LCSH)
Language: English
Date Of Record Creation: 2015-12-19 17:59:47 (W3C-DTF)
Date Of Record Release: 2015-12-19 23:03:29 (W3C-DTF)
Date Last Modified: 2015-12-19 23:05:05 (W3C-DTF)

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