Title: Immunoidentification of trypanosoma cruzi antigens using Sera from chronically infected patients
Author: Hiliana Patricia Aristizabal Pineda
Institution: Institute of Tropical Medicine and International Health, Berlin
Graduate date: 2015-04-29 (W3C-DTF)
Document: Aristizabal Pineda_ABSTRACT.pdf
The main objective of this study was to search for the most immunoreactive native proteins of Trypanosoma cruzi (T. cruzi) by carrying out a serological analysis of anti-T. cruzi antibodies in sera from patients with Chagas disease. Following this, an immunoreactive analysis of potential antigens was performed. Next, a group of sera where chosen to search for IgM and IgG antibodies by in-house ELISA, which was optimized in this study. The most reactive sera detected by ELISA were used for a profile analysis of the proteins by western blotting in order to identify the predominant immunogenic proteins from T. cruzi that develop humoral immune response in patients in the chronic stage of Chagas disease
Classification: 2015 (LCSH)
Language: English
Date Of Record Creation: 2015-05-06 05:35:57 (W3C-DTF)
Date Of Record Release: 2015-05-06 10:48:28 (W3C-DTF)
Date Last Modified: 2015-05-06 11:13:03 (W3C-DTF)

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