Title: Molecular Parasitology: The biology, diagnosis, epidemiology, taxonomy, vaccines & drug resistance of parasites of medical importance & their vectors
Keywords: Tropical medicine
Research (in general)
Laboratory science (incl.. quality assurance)
Country: Portugal
Institution: Protugal - Instituto de Higiene e Medicina Tropical , Universidade Nova de Lisboa
Course coordinator: Henrique Silveira
Date start: 2018-04-19
Date end: 2018-05-24
About duration and dates: 5 weeks, Thursdays and Fridays from 13:00 to 20:00
Classification: advanced optional
Mode of delivery: Face to face
Course location:
Instituto de Higiene e Medicina Tropical
Universidade Nova de Lisboa
Rua da Junqueira Nº 100
1349-008 Lisboa
ECTS credit points: 6 ECTS credits
SIT: Contact: 56 hours
Self study: 112 hours
Language: English
At the end of the module the student should:
1. Recognise the importance of molecular biology for the study of the major parasites of medical importance and its application on research;
2. Recognise and explain the molecular mechanisms associated with the life cycle of various parasites of medical importance;
3. Identify and evaluate molecular techniques applied to the diagnosis, epidemiology, taxonomy, vaccines and drug resistance, as well as assess their application to new situations;
4. Explain diversity in the context of epidemiology, evolution and population genetics;
5. Plan and perform practical laboratory techniques;
6. Revise critically, communicate and discuss material published in the medical field of molecular parasitology (seminars and tutorials).
Assessment Procedures:
If students do not attend at least two thirds of the lessons, they are automatically dismissed from the course without any refund.
The final assessment of the student will have two components:
1. Seminars – where the ability to understand, bibliography search, critical judgment, synthesis, and communication will be evaluated. It represents 50% of final grade, based on the following weighting: 20% presentation, 20% performance in the discussion, and 10% - participation in the discussion of papers presented by colleagues.
2.Written reports of practical lessons (5 in total) (3-5 pages containing: Introduction, materials and methods, results and discussion). It represents 50% of final grade.
If students do not reach 10 out of 20 as the final mark a written exam will be performed 1-2 weeks after the end of the module.
Lectures (L), practical laboratory classes (P), seminars (S)
Lesson # 1 - Introduction to molecular parasitology. Life cycle and molecules. (L - 1½h).
Lesson # 2 - Molecular taxonomy and evolution. (L - 1½h).
Lesson # 3 - Molecular mechanisms of cell invasion and mobility – Apicomplexa. (L - 1½h).
Lesson # 4 - Molecular mechanisms of cell invasion and mobility – trypanosomatids. (L - 1½h).
Lesson # 5 - Phylogeny, population biology and vector control. (L - 1½h).
Lesson # 6 - Molecular basis of insecticide resistance. (L - 1½h).
Lesson # 7 - New molecular approaches for the analysis of entomological parameters of medical importance. (P – 6h).
Lesson # 8 - Antigenic variation in Plasmodium. (L - 1½h).
Lesson # 9 - Antigenic variation in Trypanosoma. (L - 1½h).
Lesson # 10 - Molecular techniques applied to the study of intestinal parasites. (P – 3h).
Lesson # 11- Parasite glycobiology. (L - 1½h).
Lesson # 12 - Applications and methods used in transfection of animal cells and bacteria. (L - 1½h).
Lesson # 13 - Gene Expression. (P – 6h).
Lesson # 14 - Resistance to antimalarials. (L - 1½h).
Lesson # 15 - Mechanisms of drug resistance in Leishmania. (L - 1½h).
Lesson # 16 - Molecular typing of Leishmania. (P – 3h).
Lesson # 17 - Resistance to anthelmintic drugs: genetics and epidemiology. (L - 1½h).
Lesson # 18 - System Schistosoma/mollusc: resistance or susceptibility? (L - 1½h).
Lesson # 19 - Detection of Schistosoma mansoni in Biomphalaria glabrata. (P – 6h).
Lesson # 20 – Seminars - Applications of microarrays in parasitology. Students have to read a paper, analyse it critically and present a critical summary to the other students and teachers (S – 3h).
Tutorials – To discuss published scientific articles, revise contents of lectures, assist on the elaboration of reports or any matter of students interest related to the course (5h).
During the course there will be lectures, practical laboratory classes, seminars, group work and tutorials. See above for distribution of time and learning methods used for each lesson
Lectures: 24h
Laboratory practical: 24h
Seminar: 3h
Tutorials: 5h
Self-study: 112h
- Students should be proficient (Write, listen, read and speak) in English or Portuguese.
Level of English proficiency expected: TOEFL test score 213 computer-based or 550 paper-based or 79-80 internet-based or IELTS band 6.0.
- Students must have a degree in life sciences or similar.
max. number of students: 20;
max. number of tropEd students: 5
If more then 20 students apply to the course, they will be ranked according to the grade obtained in their previous degree.
720 Euro;
tropEd accreditation:
Accredited in February 2013. This accreditation is valid until February 2018.
This module is part of the IHMT post-graduate program in Biomedical Sciences (MSc and PhD)
Email Address: mrfom@ihmt.unl.pt
Date Of Record Creation: 2013-02-25 03:55:02 (W3C-DTF)
Date Of Record Release: 2017-10-02 10:55:19 (W3C-DTF)
Date Record Checked: 2017-10-02 (W3C-DTF)
Date Last Modified: 2017-10-22 20:55:17 (W3C-DTF)

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